Blar i forfatter "Ziegler, Mathias"

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    • Early Evolutionary Selection of NAD Biosynthesis Pathway in Bacteria 

      Sharma, Suraj; Hsieh, Yin-Chen; Dietze, Jørn; Bockwoldt, Mathias; Strømland, Øyvind; Ziegler, Mathias; Heiland, Ines (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-21)
      Bacteria use two alternative pathways to synthesize nicotinamide adenine dinucleotide (NAD) from nicotinamide (Nam). A short, two-step route proceeds through nicotinamide mononucleotide (NMN) formation, whereas the other pathway, a four-step route, includes the deamidation of Nam and the reamidation of nicotinic acid adenine dinucleotide (NAAD) to NAD. In addition to having twice as many enzymatic ...

    • Identification of evolutionary and kinetic drivers of NAD-dependent signaling 

      Bockwoldt, Mathias; Houry, Dorothee; Niere, Marc; Gossmann, Toni I.; Reinartz, Ines; Schug, Alexander; Ziegler, Mathias; Heiland, Ines (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-24)
      Nicotinamide adenine dinucleotide (NAD) is best known as an essential cofactor of biochemical reactions. In addition, it is involved in the regulation of virtually all major cellular events. These NAD-dependent regulatory functions are mediated by enzymes (e.g., sirtuins, poly–adenosine -diphosphate [ADP] ribose polymerases, ADP-ribosyl cyclases) that cleave the molecule to liberate nicotinamide ...

    • Keeping the balance in NAD metabolism 

      Strømland, Øyvind; Niere, Marc; Nikiforov, Andrey; Van Linden, Magali R; Heiland, Ines; Ziegler, Mathias (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-09)
      Research over the last few decades has extended our understanding of nicotinamide adenine dinucleotide (NAD) from a vital redox carrier to an important signalling molecule that is involved in the regulation of a multitude of fundamental cellular processes. This includes DNA repair, cell cycle regulation, gene expression and calcium signalling, in which NAD is a substrate for several families of ...

    • Model of Tryptophan Metabolism, Readily Scalable Using Tissue-specific Gene Expression Data 

      Stavrum, Anne-Kristin; Heiland, Ines; Schuster, Stefan; Puntervoll, Pål; Ziegler, Mathias (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Tryptophan is utilized in various metabolic routes including protein synthesis, serotonin, and melatonin synthesis and the kynurenine pathway. Perturbations in these pathways have been associated with neurodegenerative diseases and cancer. Here we present a comprehensive kinetic model of the complex network of human tryptophan metabolism based upon existing kinetic data for all enzymatic conversions ...

    • Welcome to the Family: Identification of the NAD+ Transporter of Animal Mitochondria as Member of the Solute Carrier Family SLC25 

      Monnè, Magnus; Nikiforov, Andrey; Heiland, Ines; Agrimi, Gennaro; Ziegler, Mathias; Palmieri, Ferdinando (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-14)
      Subcellular compartmentation is a fundamental property of eukaryotic cells. Communication and metabolic and regulatory interconnectivity between organelles require that solutes can be transported across their surrounding membranes. Indeed, in mammals, there are hundreds of genes encoding solute carriers (SLCs) which mediate the selective transport of molecules such as nucleotides, amino acids, ...